Ingredients Review: NEW Estée Lauder Advanced Night Repair Intense Reset Concentrate

• The Claims: Estée Lauder Advanced Night Repair Intense Reset Concentrate

It is not surprising that healthy sleep can bring better skin. Why? The skin follows the same circadian rhythm as the rest of our body. When we snooze, vital regeneration and cell turnover processes almost double (yes, double), and the production of collagen increases, making it the best time to restore skin tone.

Fortunately, you can also enhance this process with a tailored nightly skincare regimen. Estée Lauder has most recently launched the newest sleep innovation: targeted anti-oxidant packed formula, Advanced Night Repair Intense Reset Concentrate.

This breakthrough overnight treatment, with Chronolux™ S.O.S. technology, rescues and resets the look of skin fast. Immerses skin in sustained, 24-hour moisture with 15X concentrated Hyaluronic Acid in a multi-molecular weight complex.

• Ingredients/Efficacy: Estée Lauder Advanced Night Repair Intense Reset Concentrate

(image from CosDNA Cosmetic Ingredients)

There are three cores in the product: Autophagy, Gene Rhythm, Stratum Corneum Thickening and Protection.

Autophagy

The Nobel Prize in Physiology in 2016, it is actually the selective dissolution of cells. During the cell life cycle, the damaged, end-of-life part of the organelles, long-lived proteins and nucleic acids are transported into the enzyme by the autophagosome, hydrolyzed into peptide chains, and then further hydrolyzed into amino acid fragments to become NMF moisturizing factors, as well as new cells' nutrient.

This autophagy process is closely related to cellular inflammation and aging. Autophagy can inhibit the formation of inflammatory signaling protein complexes, down-regulate the activity of NF-KB, and inhibit the production of inflammatory factors such as interleukin L by eliminating damaged mitochondria.
Moreover, autophagy products can re-hydrolyze cell waste into cell nutrients.

Estee Lauder is simulating this autophagy and activating the autophagy process.

Yeast Extract and Salicylic Acid were used as autophagosome activators to activate the AMPK protein kinase and MAP-_LC3 genes to inhibit mTOR signaling.

Hydrolyzed Sodium Hyaluronate is used as an enzyme solution activator. The autophagosome transports cell waste into the enzyme solution and hydrolyzes it into a beneficial substance. This patent accelerates the process of autophagy

Regulating Cell Rhythm

The proven rhythm genes are CLOCK and PER1, which produce protein when sleeping at night.
Specifically, the tripeptide-32 rhythm-type peptide was used to regulate the PER1 gene, allowing it to remain operational at night. DNA repair enzymes (that is, lactobacillus ferment) can repair several types of cell damage during the day, while resveratrol inhibits NAD, activates SIRT-1, controls cell division scale, increases cell survival rate, and prolongs cell life cycle.
This combination has a significant effect on the protection of photoaging damage and the improvement of cell survival rate.

Therefore, Autophagy and Gene Rhythm are combined to make this Estée Lauder Advanced Night Repair Intense Reset Concentrate.

For dead cells, accelerate metabolism, produce nutrients for new cells, and open damaged gene channels at night to speed up repair, while continuously releasing beneficial substances and prolonging the cell life cycle.

Together, it is the patented Chronolux™ S.O.S mentioned by Estee Lauder. Corresponding to the ingredient list, it should be Yeast Extract, Salicylic Acid, Tripeptide-32, Resveratrol, Lactobacillus Ferment

Quadruple Hyaluronic Acid Thickening Stratum Corneum

Then the bottle also used four different types of hyaluronic acid, which are cross-linked HA, macromolecular HA, hydrolyzed small molecule HA, and plant polysaccharide fragments.

The four types of hyaluronic acid in different parts of the skin, internal stimulation of the formation of extracellular matrix, full and firm skin, maintain the barrier function, external macromolecules linked to the network, reduce the loss of water through the epidermis, and resist external damage.

• Which Skin Type It Is For?

The good thing about Estée Lauder Advanced Night Repair is that is should be generally safe, even for people with sensitive skin. It is a great moisturizer, and the company advises it for use in people above 25 years old.

• Differences between Estée Lauder Advanced Night Repair Synchronized Recovery Complex II and the Newest One
  

Advanced Night Repair Synchronized Recovery Complex II is mainly used for reducing wrinkles and prevent or reverse damage caused by the sun owing to its excellent anti-aging ingredients. It uses ChronoluxCB patented technology and Bifida Ferment Lysate, which can activate the skin's self-repairing power, leaving the skin soft, translucent and youthful.

It doesn't conflict with the use of Advanced Night Repair Intense Reset Concentrate. They can be used together to have better effects.