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Probiotic Shootout: Life Extension vs. Garden of Life vs. Seed vs. Nature's Bounty?

Probiotic Shootout: Life Extension vs. Garden of Life vs. Seed vs. Nature's Bounty?

    More and more studies show that the balance or imbalance of bacteria in your digestive system is linked to overall health and disease. Probiotics promote a healthy balance of gut bacteria and have been linked to a wide range of health benefits. Probiotics are excellent for introducing good bacteria into your digestive system. They provide health benefits ranging from aiding digestion to alleviating common gastrointestinal conditions. Life Extension, Garden of Life, Seed, and Nature's Bounty are popular probiotic brands, but which one is better? How do you know which one is best for you? Here we reviewed these four brands to help you find the best probiotic supplements for your daily life, evaluated quality, pros & cons, and prices and determined which one is best for you.

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Probiotics come in various different forms and often target different issues (you can buy probiotics specifically for bloating, probiotics for men or probiotics for women) so it can be difficult to know what to buy. In addition, depending on your needs, you may want to choose a single or multi-strain probiotic. If you’re unsure about the type of probiotic or dosage that you should be taking, ask a healthcare professional for advice.

Life Extension Reviews

Life Extension develops and supplies nutritional supplements with a focus on high-quality, pure, and potent ingredients.

With over 40 years of experience in the health and wellness space, Life Extension is a popular brand that offers a huge range of high-quality supplements. The company strives to help people live longer, healthier lives through its line of science-backed nutritional products. 

According to the company, all vitamins and supplements are formulated with pure, independently sourced ingredients. Life Extensions has a strong focus on innovation, and the company’s researchers are continually pushing boundaries to ensure products are years ahead of competitors.


Perhaps the most compelling reason to choose Life Extension over other companies is its assurance that you’re getting the highest quality and best purity of ingredients. When you buy from Life Extension, you can be guaranteed that what you read on the label is what you get.

  • Life Extension’s focus is on the purity of ingredients over cost. This reduces contaminants such as heavy metals.

  • Only ingredients that have been shown to be successful in scientific studies are used.

  • Adheres to NSF International good manufacturing practices that include bi-annual audits of manufacturing systems and distribution methods.

  • The vast majority of products are non-GMO.

  • Truth in advertising - Life Extension doesn’t use vague or misleading terms like “organic” or “free of excipients” to try to mislead customers.

Pros & Cons 


Offers one of the best selections online for 

nutritional supplements.

Some products are more expensive than those of other companies - but you pay for quality.

Rigorously tests all products sold, ensuring customers get the most effective, potent, and 

pure products-with no exceptions.

Some customers report that shipping can be 


Significant discounts and incentives for bulk 

orders and repeat purchases.

Not a huge selection of mushrooms.

A wide array of products to browse on the site.

Supplement quiz to help customers find the 

right supplements for their needs.

100% satisfaction guarantee for one year.

Free access to wellness specialists.

Life Extension Probiotics

1. FLORASSIST GI with Phage Technology

Florassist Gi with Phage Technology is our best in class probiotic formula. It promotes digestive health, proper nutrient absorption, and a healthy balance of bacteria in your intestines. It does this with two important blends: a tetraphage blend of innovative bacteriophages, and Life Extension's proprietary probiotic blend.

  • Dual Encapsulated Probiotic Blend for Intestinal Health

  • Gluten Free

  • Dietary Supplement

  • Non-GMO LE Certified

  • Proprietary probiotic blend

Florassist gi doesn’t deliver just one probiotic strain, but six: l. Acidophilus la-14, b. Lactis bl-04, l. Paracasei lpc-37, l. Rhamnosus lr-32, b. Bifidum/lactis bb-02 and b. Longum bb536®. Together, there are 15 billion colony forming units (or cfus) per capsule of these probiotic strains.

Florassist gi utilizes a dual-encapsulation softgel that protects the probiotics inside, delivering an unprecedented amount of live bacterial colony forming units (cfus) to where the body needs them most. Furthermore, the strains selected for their probiotic blend are particularly acid-resistant, so maximal amounts of the beneficial probiotics get to your intestinal tract where they can promote optimal digestion.



FLORASSIST Balance probiotic formula has seven strains of Lactobacillus and Bifidobacterium probiotics to optimize digestive health, promote healthy immune response and support whole-body health.

  • Gluten Free

  • Non-GMO LE Certified

  • Dual Encapsulated Probiotic Blend for Overall Health

  • Dietary Supplement

FLORASSIST Balance now delivers SEVEN probiotic strains: B. breve Bbr8; L. plantarum 14D; B. animalis ssp. lactis BLC1; L. paracasei IMC 502; L. rhamnosus IMC 501; L. acidophilus LA1; B. longum ssp. longum SP54. Together, there are 15 billion colony forming units (or CFUs) per capsule of these probiotic strains.


Life Extension Promotions

Where to Buy Probiotic Supplements?

You can buy probiotic supplements at brands' official website (like You can also giHerb.comWalmart.comWalgreens or to purchase probiotic supplements

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Garden of Life Reviews

For more than 14 years, Garden of Life’s mission has been Empowering Extraordinary Health. The human body craves the nutrition found in food, and Garden of Life's goal is to feed that need with cleanest, highest quality whole-food ingredients possible. No synthetic nutrients, artificial flavors, sweeteners or chemical preservatives are ever added to their products.

The organic vitamins, doctor-formulated probiotics and plant-powered proteins you'll find in this line provide fuel and nourishment from real fruits, vegetables, herbs and superfoods, with many formulas bearing the USDA Certified Organic and Non-GMO Project Verified seals.

Garden of Life’s commitment to health goes beyond offering some of the most effective nutritional products in the world. Of equal importance is their quest to preserve the integrity of the planet through eco-friendly initiatives and by supporting relevant philanthropic organizations throughout the world in desperate need of help.


In Regards to Quality Control, Garden of Life Products:

  • are safely manufactured by cGMP (current Good Manufacturing Practices) third-party audited facilities.

  • are tested to be safe, conforming to the FDA’s Good Manufacturing Practices and food standards in regulated labs. (These are testing methods that apply to whole food supplements—food for ingredients versus synthetic supplements.)

  • have a full-time Quality Control Department dedicated to ensuring all appropriate quality practices are met.

  • are tested by the leading third-party independent testing agency, [agency name].

  • are up to standards, such as those requiring Certified USDA Organic products that are safe from toxic pesticides and fertilizers.

  • are meeting standards of the Non-GMO Project and are Non-GMO Project Verified—safe from genetically modified ingredients.

Additionally, their proteins are Trusted for Sport by Informed-Choice—safe for competitive use and free of banned substances. 

Furthermore, they launched “first and only” whole food multivitamins in 2014—mykind Organics—which are fingerprint analyzed for each of the botanical ingredients in the proprietary blend.

Pros & Cons  

  • Clean whole food ingredients

  • Contains a probiotic and enzyme

  • Certified USDA Organic (no toxic pesticides or residues)

  • Strand blend that may upset some users

  • Non-GMO Project Verified products (Independent 3rd Party Certification)

  • Taste and texture can be somewhat chalky

  • Innovative, science-driven formulas

Garden of Life Probiotics

Garden of Life offers a wide array of probiotic formulas with diverse strains to support everyone’s digestive and immune health, plus much more. 

  • Ages 50+

  • Kids & Baby

  • Men

  • Prebiotics &

  • Postbiotics

  • Prenatal

  • Women

Here list two best sellers.

1. Dr. Formulated Probiotics Once Daily Women's Shelf-Stable

Formulated by America's Brain-Health Expert, a Board-Certified Neurologist, #1 New York Times best-selling author, Fellow of the American College of Nutrition, and expert in the human Microbiome.

Dr. Perlmutter created this unique formula exclusively for Women, with a high count of beneficial probiotics made from diverse strains that are resistant to stomach acid and bile, to support women's digestive and immune system health.

Promotes Women's Health - with added L. reuteri and L. fermentum.

Digestive & Immune System Support - 50 Billion CFU, 16 probiotics.

Innovation - New desiccant-lined bottle technology for shelf stable probiotics.

  • Shelf Stable - Potency Promise

  • No Refrigeration Required

  • Vaginal + Digestive + Immune System

  • 50 Billion Guaranteed - 16 Probiotic Strains

  • Supports Women's Health

  • Supports Immune System & Digestive Health

  • Non GMO Project Verified

  • Gluten Free

  • Dairy Free

  • Soy Free

  • Raw Probiotic Supplement

  • Vegetarian


2. Dr. Formulated Probiotics Mood+ Shelf-Stable

Emerging science is showing a link between gut and brain health. Dr. Perlmutter created this unique formula, with clinically studied probiotics, Ashwagandha and Blueberries, to support emotional well-being and relaxation.

Emotional Well-Being - Contains L. helveticus R0052 and B. longum R0175 in the amount clinically shown to support mood and relaxation.

Digestive & Immune System Support  - 50 Billion CFU, 16 Probiotics.

Stress Management - Contains 350 mg of Ashwagandha and Blueberries.

  • No Refrigeration Required

  • Mood + Digestive + Immune System

  • 50 Billion Guaranteed

  • 16 Probiotic Strains

  • Promotes Emotional Well-Being & Relaxation

  • Promotes Digestive Balance

  • Non GMO Project Verified

  • Gluten Free

  • Raw Probiotic Supplement

  • Certified B Corporation

  • Vegetarian


Garden of Life Promotions

  • Subscribe & save 10% on your 1st order;

  • FAST and FREE Shipping on orders over $25.

Seed Reviews

Seed is an e-commerce brand that sells a daily synbiotic that is formulated to boost microbial health. The company got its start in 2018 when cofounders Ara Katz and Raja Dhir determined that the current probiotic supplements available weren’t hitting the mark. Katz’s experiences of pregnancy and breastfeeding as a new mom led her to develop a deeper appreciation of the body’s microbiome and its role in overall health. She joined forces with Dhir, who had the scientific experience to understand what could be improved within the probiotic industry.

Together, they strove to create a supplement that “raised the bar on bacteria” by giving the body what it needed for all its systems to operate most effectively.  Marketed as a monthly subscription service, this company has the backing of a team of certified scientists, doctors, and entrepreneurs that believe that this supplement can be used in reinvigorating the digestive system.

With a steady following of over 125K on Instagram, Seed has been spotlighted by various media outlets including Fast Company, Forbes Magazine, and Business Insider.


  • Seed PDS-08 Pediatric Daily synbiotic undergoes extensive testing throughout each step of the manufacturing process as well as on the final product. This includes whole-genome sequencing on their strains (translation: they know which strains are present and in which quantities), flow cytometry (flow cytometry measures Active Fluorescent Units—a more accurate way of measuring all viable cells), survivability testing to ensure the optimal conditions for their probiotics to survive transit through the GI tract, heat and humidity testing to mimic the most extreme conditions their product may encounter during shipping and storage, and over 50 quality-assurance and quality-control (QA/QC) checkpoints.

  • The final product is tested for 420 different pesticides (including glyphosate) and over 20 of the most common allergens as defined by the European Food Safety Authority (EFSA). Their probiotic strains have GRAS and/or QPS status, which designates them as safe for consumption by the United States and European Union, respectively.

  • They monitor purity under both U.S. and European protocols (including cGMP + HACCP) throughout the production cycle with lot-to-lot testing (this means they test each ingredient batch prior to encapsulation and each batch after manufacture).

Pros & Cons 

What We Like 

  • The company shares detailed information about every bacterial strain within the supplement and links out to the scientific studies highlighting their effectiveness.

  • Customer reviews on Facebook and other review sites show that Seed probiotics work as described for many users. 

  • Those with allergies or food sensitivities will also appreciate these supplements are soy-free, vegan, gluten-free, dairy-free, corn-free, and free of binders and preservatives.

  • From a consumer standpoint, Seed makes taking probiotics simple. The shelf-stable formula means you won’t have to store them in the fridge, and each 30-day supply is guaranteed to remain viable for 18 months after opening. Likewise, the nested capsule delivery system should improve how many billions of bacteria make it into your digestive system intact.

  • Equally noteworthy, we love Seed’s commitment to environmental sustainability. By sending each customer two reusable glass containers at the start of their subscription, the company minimizes the packaging waste for each subsequent order.

What We Don’t Like

  • Despite these positives, Seed broad-spectrum probiotics have some downsides. To start, they are pricier than many competitors. You will pay $1.66 per day’s dose, which is more than some want to pay for supplements.

  • It’s also not possible to try them without committing to a monthly subscription. While it will take several weeks or longer to start noticing their effects, some customers might not want to be locked into an auto-ship program so early in the experimenting process.

  • Finally, it’s currently only possible to pre-order these supplements. If you’re dealing with digestive distress today, you may want to try a probiotic brand that’s available right now for faster relief.

Seed Probiotics

Seed totally offers two items: DS-01 Daily Synbiotic and PDS-08 Pediatric Daily Synbiotic.

1. DS-01 Daily Synbiotic For Adults (18+)

  • Price for $49.99 / month at Seed

Seed’s DS-01 combines 24 clinically and scientifically studied probiotic strains (not found in yogurt, most supplements, or fermented foods and beverages) with a non-fermenting prebiotic compound concentrated from Indian pomegranate.

It’s among the first to take a Microbe-Systems Approach with strain-specific benefits beyond digestive health, including skin health, heart health, gut immune function, gut barrier integrity, and micronutrient synthesis. It’s also among the first formulations to include a strain that synthesizes folate and increases production within the body.

Adults—take 2 capsules daily, all at once. Preferably on an empty stomach to limit exposure to digestive enzymes and bile salts. However, you know your body best—if it’s more comfortable for you to take with food, please feel free to do so.


2. PDS-08 Pediatric Daily Synbiotic For Kids + Teens (3-17)

  • Price for $39.99 / month at Seed

PDS-08 Pediatric Daily Synbiotic is a clinically studied 2-in-1 powdered probiotic + prebiotic, formulated for children and adolescents ages 3-17 with 9 probiotic strains and a fiber-based prebiotic.

1. Easy, frequent bowel movements.

Studied in a pediatric population to support digestive function and regular, healthy bowel movements in children with fewer than five bowel movements per week.

2. Promotes healthy regularity.

Maintains healthy bowel movement regularity among non-constipated children without creating hyper-frequency of bowel movements.

3. Exceptionally well tolerated.

No observed side effects or GI distress (such as pain, bloating, gas, diarrhea) as commonly reported with many fiber-based dietary supplements, probiotics, and high-dose fermentable prebiotics.

4. Increase of Bifidobacterium.

Significantly enriches Bifidobacterium in the pediatric gut microbiome as demonstrated via metagenomic shotgun sequencing.

5. Production of Short-Chain Fatty Acids in vitro.

Significant increase in the concentration of SCFAs present in the colon compartment of SHIME, suggesting that PDS-08 supports the production of SCFAs in the lower gut.


Seed Promotions

Nature's Bounty Reviews

Health-conscious people have trusted Nature’s Bounty products for decades. Their dedication to quality, consistency, and scientific research has resulted in vitamins and nutritional supplements of unrivaled excellence. By combining the latest breakthroughs in nutritional science with the finest ingredients, They’re proud to provide you with supplements of unsurpassed quality and value. The types are as follows:

  • Advanced Men's Series

  • CoQ-10 Supplements

  • Gummies

  • Stress Comfort

  • Fish Oil & Omegas

  • Hair, Skin and Nails

  • Herbs

  • Letter Vitamins

  • Minerals

  • Melatonin

  • Multivitamins

  • Protein Powder

  • Probiotics

  • Specialty Supplements

Nature’s Bounty is the flagship brand of The Bountiful Company, a family of wellness brands committed to providing people with high quality products to complement their lifestyles and physical health. 


Nature's Bounty supplements are overseen by their scientists, manufacturing specialists and quality experts, each one dedicated to maintaining the highest quality standards. As part of their commitment to quality, Nature’s Bounty only uses ingredients from suppliers that meet their stringent Quality Assurance Standards, as well as GMP supplement quality standards. Every Nature’s Bounty product is subjected to numerous quality tests and assays throughout the manufacturing process to verify purity and full potency. As an added measure of quality assurance, the initial ingredients, as well as the final product are tested in their microbiological laboratory to make certain that the product is pure and free of harmful bacteria.

At Nature's Bounty, they don’t just test and retest their products, they put their people and even their laboratory to the test, too. They’re proud that their facilities have been successfully audited by the United States Pharmacopeia and STR (Specialized Technology Resources), a leading independent dietary supplement quality evaluation firm.

Pros & Cons 

What We Like 

  • As part of their commitment to quality, Nature's Bounty only uses ingredients from suppliers that meet their stringent Quality Assurance Standards, as well as GMP supplement quality standards.

  • Every Nature’s Bounty product is subjected to numerous quality tests and assays throughout the manufacturing process to verify purity and full potency. 

  • In addition, At Nature's Bounty, they don’t just test and retest their products, they put their people and even their laboratory to the test, too. Their facilities have been successfully audited by the United States Pharmacopeia and STR (Specialized Technology Resources), a leading independent dietary supplement quality evaluation firm.
What We Don't Like 

  • The official website does not offer sales and can only be purchased through third-party websites.

Nature's Bounty Probiotics

1. Nature's Bounty, Acidophilus Probiotic

  • Price for $11.53 at iHerb (120 Tablets)

  • Price from $13.98 at Walmart (200 Tablets)

  • Price for $12.96 at Aamazon (200 Tablets)

Acidophilus is a friendly bacteria for the digestive system. Nature’s Bounty Probiotic Acidophilus contains over 100 million active Lactobacillus Acidophilus (including the naturally occurring metabolic product produced by Lactobacilli) at the time of manufacture.

  • 100 Million Organisms

  • Friendly Bacteria for the Digestive System

  • Digestive Health

  • Dietary Supplement

  • Lactobacillus Acidophilus La-14

  • Guaranteed Quality

  • Laboratory Tested

  • Sodium Free

  • Suitable for Vegetarians


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